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Livestock Agents| Toxins | Viruses | Secondary agents | Biological Agent Code Names

Secondary Biological Agents: Hepatitis A virus to Lyssavirus

 

Hepatitis A virus Hog cholera virus Infectious conjunctivitis virus
Influenza virus Kyasanur forest virus Legionella pneumophila
Louping ill virus Lyssa virus Secondary agents list

 


Hepatitis A virus
Disease Name Hepatitis type A
Synonyms
  • Hepatitis
  • Hepatitis A
  • Viral hepatitis
Agent Type Virus
Target Humans
Related Agents None
Listed by the
Australia Group
No
Comments Hepatitis A virus is reported to have been studied as a possible biological weapon by South Africa. The disease is quite widespread and is usually spread as a result of poor personal hygiene and can be a problem in day care centers, refugee camps and amongst troops in the field. Diagnosis is also technically easy.

The disease has an incubation period that is relatively long for a biological weapon at 3-4 weeks but the onset of the disease is abrupt and victims become exhausted and develop jaundice as their livers lose function. Victims typically take about 10 weeks to recover. The disease is rarely fatal and victims have lifelong immunity.

The virus is quite hardy and can withstand relatively harsh chemical treatments and can survive outside the body for days. Hepatitis A is endemic in the Middle East and a number of Palestinian suicide bombers were identified as carriers of the virus.

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Hog cholera virus
Disease Name Hog cholera
Synonyms
  • Classical swine fever
  • Classical swine fever virus
  • CSFV
  • HCV
  • Swine fever
Agent Type Virus
Target Livestock (swine)
Related Agents
Listed by the
Australia Group
Yes
Comments A highly infectious and effective killer of pigs that can kill up to 90% of a herd.

The disease resembles cholera in that it involves a violent diarrhea but differs in being accompanied by a fever and involving vomiting. The nervous system can also be affected. Infected sows may abort fetuses or farrow piglets with brain damage. Like many related viruses, it can cause hemorrhages.

The virus is killed by drying but can survive in a damp environment and in body fluids.

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Infectious Conjunctivitis Virus
Disease Name Infectious conjunctivitis
Synonyms Viral conjunctivitis
Agent Type Virus
Target Humans
Related Agents None
Listed by the
Australia Group
None
Comments An infectious conjunctivitis virus was among the agents studied by Iraq. The disease is considered to be an ingenious agent against troops in the field because it takes away the most crucial of the senses: sight. The disease does not blind, but inflames the protective conjunctiva of the eye and degrades vision to the point that doing anything requiring good vision, such as aiming weapons or reading maps or instruments becomes very difficult.

Treating the symptoms and use of dark glasses are often effective in treatment, although the disease will clear up by itself.

There are three viruses that cause conjunctivitis:

  • Adenovirus 8
  • Coxsackie virus 24
  • Echovirus 70

Although it is not clear, it seems that Iraq was experimenting with the Coxsackie virus.

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Influenza virus
Disease Name Influenza
Synonyms Flu: different outbreaks of the disease are given popular names that are related (more or less accurately) to where they were first observed or are believed to have originated, e.g. Spanish flu, Hong kong flu. Virologists give the viruses less entertaining names depending primarily on serology.

There are two major forms of the virus (types A and B) and the minor type C.

Agent Type Virus
Target Human
Related Agents Avian influenza virus
Listed by the
Australia Group
No
Comments Influenza is highly infective and spreads rapidly through the air by being coughed or sneezed out in droplets. The incubation period is brief at 1-4 days and primary symptoms are chills, fever, headache and dry cough. Typically the fever runs for three days and the respiratory symptoms for 3-4 days after that. In addition to the debilitating effects of the disease itself, it lays the lungs open to secondary disease. In the young, it can also cause an inflammation of the brain called Reye's syndrome that can be easily treated if recognized quickly.

The viruses changes rapidly with each year bringing a different variant to the fore, however, vaccination programs coupled with effective surveillance of the virus have helped to limit its spread in developed nations. Apart from HIV and some of the hemorrhagic fever viruses, the influenza virus is the only virus for which antibiotic treatment is currently available in the form of amantadine. If the drug is taken immediately upon showing symptoms of the disease, it can reduce their severity and duration.

The Spanish flu outbreak of 1918-1919 should have warned anybody paying attention about the potential of biological weapons. In less than a year it killed more people than all the armies of the empires of World War I did with over 100,000 tons of chemical weapons and hundreds of millions of rounds of artillery shells. However, it is interesting to note that in comparison to the copious records, commentaries, memoirs and histories of the even more devastating pandemics of bubonic plague, science writer Gina Kolata was able to find relatively little was ever published about the Spanish flu pandemic when she researched a book on the topic. This may indicate that even a major attack with a biological weapon may go unnoticed if it is accompanied by, or is on the heels of, a major conventional war.

Samples of the virus that caused the Spanish flu epidemic have been recovered from victims buried in the permafrost. However, no significant differences have been detected between this strain and others.

Many of the wintertime agues and aches that people call flu are usually less severe infections than influenza, which still kills and can be more unpleasant than most people believe.

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Kyasanur Forest disease virus
Disease Name Kyasanur forest disease
Synonyms None
Agent Type Virus
Target Humans
Related Agents A member of the Russian spring-summer encephalitis group of flaviviruses that includes several other potential biological warfare agents.
Listed by the
Australia Group
Yes
Comments The virus is only found in the Kyasanur forest of Northern India. outbreaks occur in the dry season as its tick vector (Haemaphyalis spinigera) begins to feed on humans. the normal hosts for the virus are local shrews and monkeys. The symptoms and course of the infection and treatment are broadly similar to those of related viruses.

The agents is not well-characterized and their is no vaccine against. this mandates that it has to be handled only in Biosafety Level 4 laboratories.

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Legionella pneumophila
Disease Name Legionnaire's disease
Synonyms
  • Legionellosis
  • Pontiac fever
Agent Type Bacterium
Target Humans
Related Agents None
Listed by the
Australia Group
Yes
Comments Legionella can be found in water just about anywhere in the world .It is actually a parasite of protozoa. Despite its distribution, it was first seen in the 1950's and then not again until there was an outbreak of a mysterious disease at an American Legion convention in Philadelphia in 1976 from which the bacterium and the disease take their names.

Although slow growing and difficult to culture, L. pneumophila is spread naturally by aerosols and is also relatively resistant to chlorination and to heat. After inhalation it can go on to develop a potentially fatal pneumonia. Pontiac fever is a milder form of the disease. The disease responds well to treatment with the antibiotics erythromycin or rifampin.

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Louping ill virus
Disease Name Louping ill
Synonyms None
Agent Type Virus
Target Humans livestock
Related Agents
Listed by the
Australia Group
Yes
Comments Louping ill virus is essentially confined to the British Isles where it can affect sheep and pheasants as economically important animals. It can also be passed to man through the bite of the tick vector Ixodes ricinus.

The disease is an encephalitis that causes an unusual gait in animals that gives it its name. It is seen by some as the mildest of the tick-borne encephalitides but it can still kill livestock and humans not given proper supportive care.

The disease can be easily diagnosed by serology and a killed vaccine is available for animals.

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Lyssa virus
Disease Name
  • Rabies
  • Lyssavirus encephalitis
Synonyms
  • Australian bat lyssavirus
  • Duvenhage virus
  • European bat lyssavirus 1
  • European bat lyssavirus 2
  • Lagos bat virus
  • Mokola virus
Agent Type Virus
Target Humans, livestock
Related Agents None
Listed by the
Australia Group
Yes
Comments

Lyssavirus is actually a group of viruses that show a great deal of similarity that leads to them often being called genotypes rather than strains or species. The group includes the causative agent of rabies (rabies virus). Rabies is an extremely severe disease of the central nervous sytem that affects any warm blooded animal and that will kill any victim that is not promptly treated with a course of vaccinations.

The symptoms are non-specific to begin with including malaise, fever, headache photophobia, loss of apettite, nausea and vomiting. Nervousness, apprehension and hallucination may follow with hydrophobia also being observed in may cases and accompanied by excessive lacrimation and sweating. Coma or paralysis follow with death coming within 2-7 days thereafter. Many members of the group are carried by bats and may be transmissible through air in aerosols of saliva. Other viruses in the group cause an encephalitis that will kill the infected animal. Rabies is the most lethal of these and the vaccine that Pasteur developed against the virus remains one of the early triumphs of microbiology. It is one of the few cases of a vaccine that is effective after the victim is infected. Although lethal and infective, lyssaviruses (rabies virus in particular) havelong and highly variable incubation periods (weeks to years). This argues against their use as battlefield weapons.

These viruses can spread from their bat reservoir to affect livestock and wildlife and occassionally to humans. In some cases they may be spread by mosquito bites.

These diseases are difficult to diagnose because the viruses do not reach appreciable numbers in the bloodstream, but are concentrated in the cerebrospinal fluid, which is more difficult to obtain.

 

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