Toxicology of trichothecene mycotoxins

Relative Acute Parenteral toxicity of the Most Abundant Trichothecene Mycotoxins

Mammals Tested

 Mouse Rat Guinea Pig Rabbit Cat Dog Pig Monkey
Trichothecene LD50(mg/kg)
T-2 Toxin 5.2 (IV)
3.0(IP)		 0.9 (IV)
3.8 (oral)
 1.0 (IV) 1.0 (IM) <0.5 (SC) - 1.2 (IV) 0.8 (IM)
HT-2 Toxin 9.0 (IP) - - - - - - -
4,15-diacetoxy
scirpenol		 12.0 (IV)
23.0 (IP)		 1.3 (IV)
0.75 (IP)
7.3 (oral)		 - 1.0 (IV) - 1.1 (IV) 0.38 (IV) -
Nivalenol 6.3 (IV)
4.0 (IP)
5.2 (SC)		 1.0 (IP) - - - - - -
Deoxynivalenol 4.3 (SC)
0.5-0.75 (IP)		 - - - - - - -
Verrucarin A 1.5 (IV) 0.8 (IV) - 0.54 (IV) - - - -
Roridin A 1.0 (IV) - - - - - - -
Satratoxin H 1.0 (IP) - - - - - -

IV: intravenous; IM: intramuscular; SC: subcutaneous; IP: intraperitoneal
Adapted from Table 34-2 of Trichothecene Mycotoxins by Robert W. Wannemacher, Jr. and Stanley L. Wiener in Textbook of Military Medicine.

Comparative Toxicity of T-2 Toxin by Various Routes of Administration

Mammals Tested

 Mouse Rat Guinea Pig Rabbit Cat Pig Monkey
Route of
Administration		 T-2 Toxin LD50(mg/kg)
Intravenous 4.2-7.3 0.7-1.2 1.0-2.0 - - 1.2 -
Intraperitoneal 5.2-9.1 1.3-2.6 - - - - -
Subcutaneous 2.1-3.3 0.6-2.0 1.0-2.0 - <0.5 - -
Intramuscular - 0.5-0.9 1.0 1.1 - - 0.8
Intragastric 9.6-10.5 2.3-5.2 3.1-5.3 - - - -
Intranasal - 0.6 - - - - -
Intratracheal 0.16 0.1 - - - - -
Inhalational 0.24 0.05 0.6-2.0 - - - -
Intracerebral - 0.01 - - - - -
Dermal in
DMSO		 6.6 4.3 2.2 10 - - >8.0
Dermal in
methanol		 - >380 >80 - - - -

DMSO=dimethylsulfoxide.
Adapted from Table 34-3 of Trichothecene Mycotoxins by Robert W. Wannemacher, Jr. and Stanley L. Wiener in Textbook of Military Medicine.

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