|
|||||||||||||||||||||||||||
| Ceftazidime |
|
|---|---|
| Biological agents targetted |
Glanders |
| Generally effective against |
Effective against a broad range of Gram-positive and Gram-negative bacteria. It is effective against bacteria resistant to ampicillin and other cephalosporins. |
| Available forms |
Usually supplied as a dry powder (Ceptaz or Fortaz) for injection or infusion. |
| Indications and usage |
Ceftazidime may be indicated in an extremely wide variety of Gram-positive and Gram-negative infections of the respiratory tract, the skin, urinary and genital tracts, septicemia, the abdominal cavity, and the central nervous system. Sensitivity of the pathogen must be demonstrated first. |
| Contraindications |
Any known adverse response to ceftazidime, other cephalosporins or beta lactam antibiotics such as ampicillin; a history of colitis or renalor hepatic insufficiency. |
| Drug interactions |
When used for prolonged treatments in combination with high levels of aminoglycoside antibiotics or potent diuretics, kidney damage has been observed. |
| Adverse reactions and side effects NOTE: all such reactions are rare. |
Pseudomembranous colitis, an unpleasant diarrhea-like disease resulting from the digestive tract being colonized by Clostridium difficile after the antibiotic has killed other bacterial in the tract is seen with ceftazidime. Other adverse reactions include:
|
| Mode of action |
Ceftazidime inhibits one the enzymes involved in the synthesis of the bacterial cell walls. The loss of the stability conferred by the wall leads to the cell lysing. |
| Structure |
 |
| Chemical names |
1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct2-en-3-yl]methyl]pyridinium hydroxide inner salt |
| CAS Registry number |
72558-82-8 |
| Synonyms
and trade names |
|
| Trade Name |
Country |
| Alfacef | South Korea |
| Ceffotan | Colombia |
| Cefortam | Portugal |
| Cefpiran | Peru |
| Ceftazim | Mexico |
| Ceftidin | India |
| Ceftim | Italy, Portugal |
| Ceftum | Indonesia |
| Ceptaz | United States |
| Cetazum | Indonesia |
| Fortam | |
| Fortax | |
| Fortaz | |
| Fortum |
Australia; Austria; Bahamas; Bahrain; Barbados; Belize; Benin; Bermuda; Bulgaria; Burkina Faso; Colombia; Costa Rica; Curacao; Cyprus; Czech Republic; Denmark; Dominican Republic; Ecuador; Egypt; El Salvador; Ethiopia; France; Gambia; Germany; Ghana; Guinea; Guyana; Honduras; Hong Kong; Hungary; India; Indonesia; Iran; Iraq; Ireland; Israel; Ivory Coast; Jamaica; Jordan; Kenya; Korea; Kuwait; Lebanon; Liberia; Libya; Malawi; Malaysia; Mali; Mauritania; Mauritius; Mexico; Morocco; Netherlands; Netherlands Antilles; New Zealand; Niger; Nigeria; Norway; Oman; Panama; Peru; Philippines; Qatar; Republic of South Africa; Republic of Yemen; Saudia Arabia; Senegal; Seychelles; Sierra Leone; Sudan; Surinam; Sweden; Syria; Taiwan; Tanzania; Thailand; Trinidad; Tunisia; Uganda; United Arab Emirates; United Kingdom; Zambia; Zimbabwe |
| Fortum Pro | Hungary |
| Fortumset | France |
| Forzid | Indonesia, Thailand |
| Ftazidime | Greece |
| Glazidim | Belgium, Finland, Italy |
| Izadima | Colombia, Mexico |
| Kefadim | Belgium; Benin; Burkina Faso; Colombia; Czech Republic; Ethiopia; Gambia; Ghana; Guinea; Ivory Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra Leone; Sudan; Taiwan; Tanzania; Tunisia; Uganda; Zambia; Zimbabwe |
| Kefamin | |
| Kefazim | Austria |
| Kefzim | Republic of South Africa |
| Magnacef | |
| Mirocef | |
| Modacin | Japan |
| Panzid | Italy |
| Pentacef | United States |
| Potendal | |
| Solvetan | Greece |
| Spectrum | Italy |
| Starcef | Italy |
| Tagal | Mexico |
| Tazicef | |
| Tazidime | Canada |
| Tazime | South Korea |
| Thidim | Indonesia |
| Tortam | |
| Waytrax | Mexico |
| Zadolina | Mexico |
| Zibac | Indonesia |
| Zytaz | India |
|