against a broad range of Gram-positive and Gram-negative bacteria
capsules, oral suspensions, tablets. Can also be formulated for
injections and intravenous drips.
is usually supplied as the hydrochloride or the hyclate (monohydrate
complex with ethanol).
for use against against a wide variety of infections when susceptibility
is demonstrated. Typically treatment begins with 2 doses of 100
miligrams on the first day followed by two doses of 50 milligrams
on following days.Specific dosage regimes are at the discretion
of the attending physician acting on information from the manufacturer
and the national authority for drug safety and use. Suggested dosages
for specific agents may be on the individual agent pages,
and other tetracyclines must not be given to women during the
last half of pregnancy or to children under the age of eight.
It can affect development of the skeleton in the fetus and can
cause discoloration and malformation of the teeth.
demonstrated sensitivity to tetracylines contraindicates use.
people may show increased sensitivity to sunlight.
used in conjunction with the anesthetic methoxyflurane there can
be severe or fatal kidney damage.
interact with anticoagulants and its effectiveness is lowered
by over the counter antacids and bismuth subsalicylate, barbiturates,
the anticonvulsants carbamazepine and phenytoin.
blocks the action of bactericidal antibiotics such as penicillins
and should not be given in combination with such antibiotics.
reactions and side effects
all such reactions are rare.
common problem is some irritation of the esophagus if capsules
are taken without food or water immediately before going to bed.
increase in blood urea nitrogen (an indicator of loss of kidney
function) is well documented.
colitis, a common side effect of intensive antibiotic therapy,is
unusual when doxycycline is used but loss of appetite, nausea,
vomiting and diarrhea have been observed. Hypersensitivity, anaphylaxis,
and exacerbation of immune disorders has been seen.Hemolytic anemia
and other disturbances of the white cell population of the blood
block protein synthesis by preventing the binding of aminoacyl-tRNA
to the ribosome. Its action is bacteriostatic (preventing the growth
of bacteria) rather than killing (bactericidal).
(Doxycycline monosodium salt with metaphosphoric acid)