Hagedorn oximes: an overview

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Hagedorn oximes: HI-6 and Hlö-7

Agents targetted

Nerve agents including:

Generally effective against

Hagedorn oximes are largely experimental drugs showing great potential in the treatment of organophosphate poisoning including organophosphorus insecticides and nerve agents.

HI-6 autoinjectors were issued to Canadian forces involved in the 1991 Gulf War.

Available forms

HI-6 is usually supplied as measured doses of a dry powder ready to be dissolved for injection. Hlö-7 is supplied as an aqueous injectable solution.

Indications and usage

Used in cases of organophosphate poisoning, either on the battlefield or in known cases of exposure to organophosphorus insecticides. Remember that Hagedorn oximes are still experimental

Contraindications

None reported.

Drug interactions

None reported.

Adverse reactions and side effects

NOTE: all such reactions are rare.

No adverse effects reported for the use of HI-6 in healthy volunteers.

Mode of action

See page on obidoxime and pralidoxime

Structure

HI-6	Hlö-7

Chemical names

HI6: Pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-, dichloride
Hlö7: Pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2,4-bis[(hydroxyimino)methyl]-, dimethanesulfonate

CAS Registry number

HI-6: 34433-31-3
Hlö7: 145613-73-6

Synonyms and trade names
(known and reported, not all may be current.)

Trade Name

Country

Asoxime chloride

Trade name for HI-6, probably used in North America.

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