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Ofloxacin |
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| Biological agents targetted | Anthrax: ofloxacin is an alternative to ciprofloxacin used when there are contraindications to the use of ciprofloxacin itself. |
| Generally effective against | More effective against Gram-negative organisms than Gram-positive ones, but active against a number of important pathogens in both groups. |
| Available forms | Oral tablets, injection, eye (ophthalmic solutions) and ear drops (otic solution) |
| Indications and usage | Recommended for use against against a wide variety of infections when susceptibility is demonstrated. May be safe for use for patients taking theophylline, warfarin, or cyclosporin. Specific dosage regimes are at the discretion of the attending physician acting on information from the manufacturer and the national authority for drug safety and use. Suggested dosages for specific agents may be on the individual agent pages, |
| Contraindications | Generally should not be given to people under 18 years of age. Any adverse reaction to other quinolones. |
| Drug interactions | Antacids containing divalent cations inhibit efficient absorption of Ofloxacin. |
| Adverse
reactions and side effects
NOTE: all such reactions are rare. |
Animal experiments indicate that Ofloxacin may interfere with bone or cartilage in very young animals. In adults, nausea, diarrhea, headache and constipation are the commonest side effects. Anaphylaxis is a risk. Levofloxacin is not carcinogenic or teratogenic in standard tests. |
| Mode of action | Ofloxacin inhibits an enzyme called DNA gyrase that is an essential component of the mechanism that passes genetic information onto daughter cells when a cell divides. |
| Structure |  |
| Chemical names | 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate Ofloxacin is a racemic mixture of which levofloxacin is the active component. |
| CAS Registry number | 8241-36-1 |
| (known and reported, not all may be current.) |
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| Trade Name | Country |
| Akilen | Indonesia |
| Apazix | Unknown |
| Baccidal | South Korea |
| Bactocin | Mexico |
| Bactoflox | Unknown |
| Danoflox | Indonesia |
| Effexin | South Korea |
| Ermofan | Unknown |
| Exocine | France |
| Favid | Unknown |
| Flobacin | Italy |
| Floxal | Germany |
| Floxan | Unknown |
| Floxil | Mexico |
| Floxin | United States |
| Floxstat | Bahamas, Barbados, Belize, Bermuda, Colombia, Costa Rica, Curacao, Dominican Republic, Ecuador, El Salvador, Guatemala, Guyana, Honduras, Jamaica, Mexico, Netherlands Antilles, Nicaragua, Panama, Puerto Rico, Surinam, Trinidad |
| Floxtat | Unknown |
| Fugacin | Unknown |
| Girasid | Unknown |
| Inoflox | Malaysia, Philippines |
| Kinoxacin | South Korea |
| Konovid | Unknown |
| Loxinter | Indonesia |
| Mefoxacin | Unknown |
| Menefloks | Unknown |
| Novecin | Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic of Yemen, Saudi Arabia, Syria, United Arab Emirates |
| Obide | Unknown |
| Occidal | Thailand |
| Octacin | Unknown |
| Ocuflox | United States |
| Ofcin | Taiwan |
| Oflocet | Australia, New Zealand, France |
| Oflocin | Italy |
| Oflodal | Taiwan |
| Oflox | Colombia, Israel, Peru |
| Ofloxan | Unknown |
| Orocin | South Korea |
| Oxaldin | Unknown |
| Qinolon | Philippines |
| Quinolon | Thailand |
| Rinolon | Unknown |
| Sinflo | Taiwan |
| Surnox | Unknown |
| Tabrin | Greece |
| Taravid | Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic of Yemen, Saudi Arabia, Syria, United Arab Emirates |
| Tarivid | Austria, Belgium, Benin, Bulgaria, Burkina Faso, Czech Republic, Denmark, Ethiopia, Finland, Gambia, Germany, Ghana, Guinea, Hungary, India, Indonesia, Irish Republic, Israel, Ivory Coast, Japan, Kenya, Liberia, Malawi, Malaysia, Mali, Mauritania, Mauritius, Morocco, Netherlands, Niger, Nigeria, Norway, Portugal, Republic of South Africa, Russia, Senegal, Seychelles, Sierra Leone, South Korea, Spain, Sudan, Sweden, Switzerland,Tanzania, Tunisia, Uganda, United Kingdom, Zambia, Zimbabwe |
| Tarvid | Unknown |
| Trafloxol | Unknown |
| Uroflox | Unknown |
| Visiren | Unknown |
| Zanocin | India |
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